Research on Fucoidan from

1: Fucoidan may be involved with the promotion of inducing tumor death.

Anticancer Res. 2004 Jul-Aug;24(4):2287-93.Links

Involvement of pattern recognition receptors in the induction of cytokines and reactive oxygen intermediates production by human monocytes/macrophages stimulated with tumour cells.

Mytar B, Woloszyn M, Macura-Biegun A, Hajto B, Ruggiero I, Piekarska B, Zembala M.

Department of Clinical Immunology, Polish-American Institute of Pediatrics, Jagiellonian University Medical College, Wielicka 265, 30-663 Cracow, Poland 

2: Fucoidan from brown seaweed shows anittumor activity.

Biosci Biotechnol Biochem. 1995 Apr;59(4):563-7.Links

Antitumor active fucoidan from the brown seaweed, umitoranoo (Sargassum thunbergii).

Zhuang C, Itoh H, Mizuno T, Ito H.

United Graduate School of Agricultural Sciences, Gifu University (Shizuoka University), Japan. 

3: Fucoidan Extract (HF) obtained from brown seaweed exhibits inhibitory effect and is a very potent antitumor agent in cancer therapy.

Anticancer Res. 1996 May-Jun;16(3A):1213-8.Links

Antitumor and antiproliferative effects of a fucan extracted from ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line.

Riou D, Colliec-Jouault S, Pinczon du Sel D, Bosch S, Siavoshian S, Le Bert V, Tomasoni C, Sinquin C, Durand P, Roussakis C.

ISOMer (Institut des Substances et Organismes de la Mer), SMAB, Laboratoire de Pharmacologie Marine, Faculté de Pharmacie, Nantes, France.

Heart Disease & Stroke Research With Fucoidan

4: Fucoidan appeared to be more effective than Heparin for preventing arterial thrombosis in this experimental model. Fucoidan also had a lower hemorrhagic (excessive bleeding) risk than Heparin (blood thinner).

Durand E, Helley D, Al Haj Zen A, Dujols C, Bruneval P, Colliec-Jouault S, Fischer AM, Lafont A.

Faculté de Médecine, Université Paris Descartes, Paris, France.

Copyright © 2008 S. Karger AG, Basel.

PMID: 18463418 [PubMed – as supplied by publisher]

Anti-Inflammatory Benefits Of Fucoidan

5: Fucoidan, sulphated polysaccharides from brown algae, was found to have anti-inflammatory effects on gut inflammation in vivo (In science, in vivo refers to experimentation done in or on the living tissue of a whole, living organism). Fucoidan suppressed IL-8 gene expression. IL-8 is a member of the supergene family of pro- inflammatory (which means capable of promoting inflammation).

Biochem Biophys Res Commun. 2008 Jul 19. [Epub ahead of print]
In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells.
Tanoue T, Nishitani Y, Kanazawa K, Hashimoto T, Mizuno M.
Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, 1-1, Rokkodai-cho, Nada-ku, Kobe, Hyogo, 657-8501, Japan.

 PMID: 18647595 [PubMed – as supplied by publisher] 

The Immune System & Fucoidan Research 

6: This study showed the defensive effects of Fucoidan from brown alga against herpes simplex virus infection.

These results suggested that oral intake of the Fucoidan might take the protective effects through direct inhibition of viral replication and stimulation of both

Innate Immune System a primary defense mechanism against invading organisms and adaptive Immune System which acts as a second line of defense.

Int Immunopharmacol. 2008 Jan;8(1):109-16. Epub 2007 Nov 20. Links

Hayashi K, Nakano T, Hashimoto M, Kanekiyo K, Hayashi T.

Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

PMID: 18068106 [PubMed – indexed for MEDLINE] 

7: Fucoidan (over sulfated) was the most potent inhibitor of tumor cell invasion and inhibited most potently and specifically the tumor cell adhesion to laminin (tissue).

Jpn J Cancer Res. 1994 Nov;85(11):1144-50.Links

Inhibitory effect of oversulfated fucoidan on invasion through reconstituted basement membrane by murine Lewis lung carcinoma.

Soeda S, Ishida S, Shimeno H, Nagamatsu A.

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University.

8: Native fucoidan is reported to have an antimetastatic (anti-cancer) activity, while animated (man made) fucoidan did not.

Cancer Lett. 1994 Sep 30;85(1):133-8. Links

Aminated fucoidan promotes the invasion of 3 LL cells through reconstituted basement membrane: its possible mechanism of action.

Soeda S, Ishida S, Honda O, Shimeno H, Nagamatsu A.

Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.

Intended for Educational purposes only.

No Claim to Government Work.

Gathered from;studies at “Fucoidan”

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